Monday, July 17, 2017

Ebook Free , by Oliver Sacks

Ebook Free , by Oliver Sacks

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, by Oliver Sacks

, by Oliver Sacks


, by Oliver Sacks


Ebook Free , by Oliver Sacks

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, by Oliver Sacks

Product details

File Size: 58919 KB

Print Length: 389 pages

Publisher: Vintage; 1 edition (April 28, 2015)

Publication Date: April 28, 2015

Language: English

ASIN: B00TCI0P24

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Amazon Best Sellers Rank:

#75,492 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

Lovely memoir, but bittersweet, I had no idea this wonderful & intellectual man past away last yr, so sad. I read some of his books back in college in the 90's & loved his approach to his scientific & medical observations, which were very funny & easy to imagine. This memoir is really just glimpses of this guy's life, given how much he wrote daily until his death, so the fact this book read so well under 400pgs is quite a feat. It could of been easily a 1,000. The amazing ppl he has encountered in his lifetime - Stephen J. Gould, Auden, DNA Crick!, gosh, I would love to have been to one their lectures, or just sitting at a table eavesdropping, w/ all these highly intellectual ppl. I would say the only real, technical chapter in the book was the 2nd to last, A New Vision of the Mind, but the rest, entertaining. I was hoping he spoke about his belief in God, given his parents were religious Jews, just more philosophical notions. Also, why he never got a laptop, since he loves to write. I wanted his thoughts on current events, like what he thought about the Internet, it doesn't seem he had a cell phone. I was surprised that the he didn't relish the modern computer era, given how the computer is like a big brain. I thought he would talk about some other issues, besides all scientific ones, like Stephen Hawk does. But oh well, overall I love this memoir, even the sexy pic for the front cover.

I fell in love with Oliver Sacks and his writing after my parents gave me "The Man Who Mistook His Wife for a Hat" this past Christmas. Ever since, I've been hooked and can't get enough. I've now read "Hat", "Hallucinations," " Musicophilia," and now his autobiography. His writing is so elegant yet lucid, that it feels as though I'm reading fiction at times. This new book of his is no different, and may perhaps be the most fascinating of them all.To say that he has lived life to the fullest would be a severe understatement; he has filled his life with enough adventure and excitement to occupy four lifetimes, and he is still going (and may he continue to do so for many years, in spite of his cancer). His openness and honesty in "On the Move" is spectacular, moving, and one feels as though he is having a fireside conversation with Sacks himself. There is so much I never knew about him, so much that I almost found hard to believe! (You'll understand this as you read through the book). What a man, what a life!As a student who will be starting his first year at medical school this August, I can say that I aspire to be half the man that Oliver Sacks has become. He is part of the reason that I have fallen even more in love with the medical field, particularly neurology and psychiatry. There is much to learn from this book, regardless of one's profession, interests, and background. There is so much more to say, but I'm no wordsmith as Sacks is, so I'll let you read it for yourself. It is my hope that you enjoy every page, sentence, and carefully crafted word that Oliver Sacks has used to print his life onto paper. As Albert Schweitzer said, "my life is my argument," and no doubt Sacks will embody this message until the end.

Oliver Sacks is one of the most important thinkers of our time. His prior works have offered considerable insight about and needed compassion toward the immensely broad spectrum of the human condition: from memory loss and divergent modes of mental processing to profound sensory limitations. Above all, he has enabled us to walk in others' shoes and imagine perceiving the world from a wholly different perspective. Not only is he a compassionate and thorough physician, he is also an extraordinary writer. His prose is compelling, vivid, and persuasive. Yet in his intellectual discourse, it is easy to focus on his mind and think of him as purely a thinker, rather than as a complete person. On the Move, a brilliant autobiography, sheds considerable insight into the rest of his life, showing his 'human' side, including passions, strengths and weaknesses. It is a fascinating chronicle of a young man who discovers his sexual orientation during a very prejudiced age, who struggles with a drinking problem, who values the life of the body (working out) as well as the mind, and who loves roaming free, whether on his motorcycle, running or scuba diving. At last, the error in the film Awakenings, in which the character supposed to be Sacks is shown as timid and barely attuned to life, is corrected. Sacks is certainly not timid, and despite medical challenges, has shown himself to be very much full of life. It is society that has been too timid, and at long last needs to embrace diversity.Paul Halpern, author of Einstein's Dice and Schrödinger's Cat: How Two Great Minds Battled Quantum Randomness to Create a Unified Theory of Physics

Both this and the earlier volume (Uncle Tungsten) are excellent autobiographies by Oliver Sacks. You would not have guessed from reading his books about neurology that he was a biker and weight lifter in his wild younger years, and also an experimenter (on himself) with drugs. He has described his shyness and a sense of a barrier between himself and others. But his autobiography is uncommonly open and self revealing. His writing made him famous and On the Move recounts his friendships with other famous people (Francis Crick, Robin Williams, etc). It is not stated in these books, but I would guess his friends and acquaintances found Dr. Sacks quite interesting and original. I hope one or more of those friends who are still with us might share their observations of this remarkable humanist/scientist.

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Saturday, July 1, 2017

PDF Ebook The Society of Genes

PDF Ebook The Society of Genes

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The Society of Genes

The Society of Genes


The Society of Genes


PDF Ebook The Society of Genes

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The Society of Genes

Review

Yanai and Lercher invite the reader to step back and observe how genes assemble together to make a global genetic system, or genome… [It] largely succeeds in translating the findings of an esoteric science into something that is easily understood… The Society of Genes represents a timely and welcome handbook for navigating this postgenomic era. (Joseph Swift Science)Using findings from the molecular revolution that only really got going in the 1980s, the authors build up a picture of networks of genes forming guilds in order to preserve their DNA dynasties… [This] lively text contain[s] a panorama of examples illustrating how genes do better by combining forces in networks. (Charalambos P. Kyriacou Times Higher Education)Yanai and Lercher use the idea of a society of genes as a vantage point from which to reintroduce the entire field of evolutionary genetics… Even experienced readers are likely to encounter perspectives that are unexpected enough to make the book worth their effort… Readers meeting biology for the first time will be well served by this richer, more nuanced, way of viewing genetics, while those with a deeper background will find plenty of interest, notably in the vivid clarity of the explanations. (Bob Holmes New Scientist)If you’re looking for a ‘what’s hot in genetics in 2016,’ this book wouldn’t be a bad place to start. It covers a huge number of topics―from the basics of genetics to genome editing, antimicrobial resistance and the functions of junk DNA… We need books like this. (Simon Hazelwood-Smith BioNews)The writing is engaging and clear, providing ample introductory material to ensure that the interested lay reader will be swept along by both the science and the evolutionary story…For the general reader, Yanai and Lercher’s discussions of cancer, immunology, sexual reproduction, and population genetics are well worth exploring. (Publishers Weekly)Written by two of the smartest young thinkers in their fields, The Society of Genes is an absorbing, thought-provoking exploration of the intersection of genetics, evolutionary biology, and society. (Eric Lander, Professor of Biology at MIT and founding director of the Broad Institute of MIT and Harvard)The Society of Genes is punchy, provocative, and timely and a must-read for us all. (Michael Levitt, Professor of Structural Biology at Stanford University and Recipient of the 2013 Nobel Prize in Chemistry)Well worth the interested reader’s attention. (M. Taylor Choice)

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About the Author

Itai Yanai is Associate Professor of Biology at the Technion–Israel Institute of Technology and a Fellow at the Radcliffe Institute for Advanced Studies at Harvard University.

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Product details

Hardcover: 296 pages

Publisher: Harvard University Press; 1 edition (January 11, 2016)

Language: English

ISBN-10: 9780674425026

ISBN-13: 978-0674425026

ASIN: 0674425022

Product Dimensions:

5.8 x 1 x 8.3 inches

Shipping Weight: 1.6 pounds (View shipping rates and policies)

Average Customer Review:

4.5 out of 5 stars

27 customer reviews

Amazon Best Sellers Rank:

#819,335 in Books (See Top 100 in Books)

I gave this book five stars because it presents a new and interesting way to explain how our genome functions. In the authors' views, genes are selfish--a Dawkins perspective--but in a holistic context; they seldom operate in isolation, but work cooperatively and competitively between and among themselves.Yanai and Lercher invoke a wonderful comparison between gene organization and operation with the economic notion of Adam Smith whereby it is the self-interested competitive and cooperative interaction of individuals that make the marketplace efficient and resilient. In like manner, it is the competitive and cooperative behavior among genes striving for their own survival that promotes the greater good of the genome society as a whole. The authors go on to make their case and they do it well. Their use of metaphors, simile, and analogy are well executed and helps the lay reader understand what is being proposed. As an economist, I got their analogy regarding the society of genes and the operation of the marketplace.This is a well written book which should be read by anyone interested in the subject...it has a refreshingly different perspective on genes and epigenetics. The reader will learn a lot about who we are and how we function.Rich

The Society of Genes is a fascinating look at the basic building blocks of all living creatures. Itai Yanai and Martin Lercher make the unique argument that genes live in cooperative societies that work together to keep the vehicle that ensures their survival alive so that they would make it to the next generation. The authors cover the nature of genes, their possible origin their defense against the many forms of danger that cells are subject to, the reproduction of genes as well as the thousands of what appear to be useless genes that travel along with the society of genes as freeloaders. The authors make it sound like genes have a life of their own and we as well as all living creatures just happen to be the fortunate vessels for their journey. I loved the book and found it difficult to put aside. The only difficulty I had was the disappointing end to the argument when they implied that we have the ability to fight against the our natures as determined by genes. They say this after having elegantly stated , “Successful management in the society of genes is not based on intelligence or intentions.” The management of proteins is solely a consequence of their molecular affinities: due to their shape and electrical charge. I was a little disappointed they did not make it clear which position they supported. Either we are subject to the laws of our physical structures or “we” have control over them. But don’t let my qualms keep you from reading this well thought out coverage of a fascinating topic; the society of genes.

I must admit I am from the field, however I often read general books like this one in order to understand how to convey complex scientific ideas to the general reader. I read most of the book over the weekend. I think it iswritten very well. It has very clear examples. It is thought provoking. Some ideas are renewed, others are novel. I truly believe it reaches a niche of clever readers who are not biology savvy.

This is an extremely interesting primer (and then some) on the nascent field of the systems biology of living systems, at least for those who are willing to write down a large number of new terms for future reference (a glossary would have been helpful). The thesis is that it is a huge society of genes within every living organism that is selfishly devoted to propating itself to future generations, not the individual gene of Peter Dawkins’ “The Selfish Gene”. The question of why remains unanswered.We learn a lot about the details of evolution, mutations, regulation of cell growth, and the cellular details of natural selection. The gene is a coherent pattern of molecules containing the information about how to make large molecules call proteins, which perform most of the functions carried out in the cell.We also learn, surprisingly, that the process is grossly inefficient. The human genome consists of 20,000 genes, and there are 1.5 billion copies of the human genome in the human body, not all containing the same genes. Only about one-third of all genes in the human genome are productively employed in the success of the human organism, while the other two-thirds are basically free loaders that trick the productive genes into carrying them along into the next generation, and the next… One is tempted to make some connection between this behavior of our genes and our own behavior as members of society.With the advent of rapid genome mapping, one can provide a genetic answer to the old question of how different are “we” and “them”. It seems that any two people on the planet are 99.9% the same in terms of their genomes, which translates into 6 million different letters out of a total 6 billion letters in the human genome, but that only about 15% of this 0.1% difference distinguishes different populations from different parts of the world. There is much more genetic variation among different populations within Africa than between European or Asian populations, which left Africa 50,000 years ago, and the present African population in the region from which they are believed to have migrated. The main difference between chimpanzees and humans is that chimps have 24 chromosomes (the famous double helix of DNA strands) and humans have 23, so that 2 of the chromosones in the common ancestor must have fused together at some time during human evolution. The genomes of chimps and humans differ by about 4%. I don’t even want to get into the oyster and fruit fly.

This book is wonderful! I found it completely accessible, and enthralling. Itai Yanai and Martin Lercher's research is insightful and may very well lead the way in a field that is ever more prevalent. I would recommend this book as a must read, in particular for anyone eager to know about the mysterious world of genetics and it's most current direction. It's clear, concise, and thought-provoking, with just the right balance of science and humanity.

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