PDF Ebook The Society of Genes
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The Society of Genes
PDF Ebook The Society of Genes
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Review
Yanai and Lercher invite the reader to step back and observe how genes assemble together to make a global genetic system, or genome… [It] largely succeeds in translating the findings of an esoteric science into something that is easily understood… The Society of Genes represents a timely and welcome handbook for navigating this postgenomic era. (Joseph Swift Science)Using findings from the molecular revolution that only really got going in the 1980s, the authors build up a picture of networks of genes forming guilds in order to preserve their DNA dynasties… [This] lively text contain[s] a panorama of examples illustrating how genes do better by combining forces in networks. (Charalambos P. Kyriacou Times Higher Education)Yanai and Lercher use the idea of a society of genes as a vantage point from which to reintroduce the entire field of evolutionary genetics… Even experienced readers are likely to encounter perspectives that are unexpected enough to make the book worth their effort… Readers meeting biology for the first time will be well served by this richer, more nuanced, way of viewing genetics, while those with a deeper background will find plenty of interest, notably in the vivid clarity of the explanations. (Bob Holmes New Scientist)If you’re looking for a ‘what’s hot in genetics in 2016,’ this book wouldn’t be a bad place to start. It covers a huge number of topics―from the basics of genetics to genome editing, antimicrobial resistance and the functions of junk DNA… We need books like this. (Simon Hazelwood-Smith BioNews)The writing is engaging and clear, providing ample introductory material to ensure that the interested lay reader will be swept along by both the science and the evolutionary story…For the general reader, Yanai and Lercher’s discussions of cancer, immunology, sexual reproduction, and population genetics are well worth exploring. (Publishers Weekly)Written by two of the smartest young thinkers in their fields, The Society of Genes is an absorbing, thought-provoking exploration of the intersection of genetics, evolutionary biology, and society. (Eric Lander, Professor of Biology at MIT and founding director of the Broad Institute of MIT and Harvard)The Society of Genes is punchy, provocative, and timely and a must-read for us all. (Michael Levitt, Professor of Structural Biology at Stanford University and Recipient of the 2013 Nobel Prize in Chemistry)Well worth the interested reader’s attention. (M. Taylor Choice)
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About the Author
Itai Yanai is Associate Professor of Biology at the Technion–Israel Institute of Technology and a Fellow at the Radcliffe Institute for Advanced Studies at Harvard University.
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Product details
Hardcover: 296 pages
Publisher: Harvard University Press; 1 edition (January 11, 2016)
Language: English
ISBN-10: 9780674425026
ISBN-13: 978-0674425026
ASIN: 0674425022
Product Dimensions:
5.8 x 1 x 8.3 inches
Shipping Weight: 1.6 pounds (View shipping rates and policies)
Average Customer Review:
4.5 out of 5 stars
27 customer reviews
Amazon Best Sellers Rank:
#819,335 in Books (See Top 100 in Books)
I gave this book five stars because it presents a new and interesting way to explain how our genome functions. In the authors' views, genes are selfish--a Dawkins perspective--but in a holistic context; they seldom operate in isolation, but work cooperatively and competitively between and among themselves.Yanai and Lercher invoke a wonderful comparison between gene organization and operation with the economic notion of Adam Smith whereby it is the self-interested competitive and cooperative interaction of individuals that make the marketplace efficient and resilient. In like manner, it is the competitive and cooperative behavior among genes striving for their own survival that promotes the greater good of the genome society as a whole. The authors go on to make their case and they do it well. Their use of metaphors, simile, and analogy are well executed and helps the lay reader understand what is being proposed. As an economist, I got their analogy regarding the society of genes and the operation of the marketplace.This is a well written book which should be read by anyone interested in the subject...it has a refreshingly different perspective on genes and epigenetics. The reader will learn a lot about who we are and how we function.Rich
The Society of Genes is a fascinating look at the basic building blocks of all living creatures. Itai Yanai and Martin Lercher make the unique argument that genes live in cooperative societies that work together to keep the vehicle that ensures their survival alive so that they would make it to the next generation. The authors cover the nature of genes, their possible origin their defense against the many forms of danger that cells are subject to, the reproduction of genes as well as the thousands of what appear to be useless genes that travel along with the society of genes as freeloaders. The authors make it sound like genes have a life of their own and we as well as all living creatures just happen to be the fortunate vessels for their journey. I loved the book and found it difficult to put aside. The only difficulty I had was the disappointing end to the argument when they implied that we have the ability to fight against the our natures as determined by genes. They say this after having elegantly stated , “Successful management in the society of genes is not based on intelligence or intentions.†The management of proteins is solely a consequence of their molecular affinities: due to their shape and electrical charge. I was a little disappointed they did not make it clear which position they supported. Either we are subject to the laws of our physical structures or “we†have control over them. But don’t let my qualms keep you from reading this well thought out coverage of a fascinating topic; the society of genes.
I must admit I am from the field, however I often read general books like this one in order to understand how to convey complex scientific ideas to the general reader. I read most of the book over the weekend. I think it iswritten very well. It has very clear examples. It is thought provoking. Some ideas are renewed, others are novel. I truly believe it reaches a niche of clever readers who are not biology savvy.
This is an extremely interesting primer (and then some) on the nascent field of the systems biology of living systems, at least for those who are willing to write down a large number of new terms for future reference (a glossary would have been helpful). The thesis is that it is a huge society of genes within every living organism that is selfishly devoted to propating itself to future generations, not the individual gene of Peter Dawkins’ “The Selfish Geneâ€. The question of why remains unanswered.We learn a lot about the details of evolution, mutations, regulation of cell growth, and the cellular details of natural selection. The gene is a coherent pattern of molecules containing the information about how to make large molecules call proteins, which perform most of the functions carried out in the cell.We also learn, surprisingly, that the process is grossly inefficient. The human genome consists of 20,000 genes, and there are 1.5 billion copies of the human genome in the human body, not all containing the same genes. Only about one-third of all genes in the human genome are productively employed in the success of the human organism, while the other two-thirds are basically free loaders that trick the productive genes into carrying them along into the next generation, and the next… One is tempted to make some connection between this behavior of our genes and our own behavior as members of society.With the advent of rapid genome mapping, one can provide a genetic answer to the old question of how different are “we†and “themâ€. It seems that any two people on the planet are 99.9% the same in terms of their genomes, which translates into 6 million different letters out of a total 6 billion letters in the human genome, but that only about 15% of this 0.1% difference distinguishes different populations from different parts of the world. There is much more genetic variation among different populations within Africa than between European or Asian populations, which left Africa 50,000 years ago, and the present African population in the region from which they are believed to have migrated. The main difference between chimpanzees and humans is that chimps have 24 chromosomes (the famous double helix of DNA strands) and humans have 23, so that 2 of the chromosones in the common ancestor must have fused together at some time during human evolution. The genomes of chimps and humans differ by about 4%. I don’t even want to get into the oyster and fruit fly.
This book is wonderful! I found it completely accessible, and enthralling. Itai Yanai and Martin Lercher's research is insightful and may very well lead the way in a field that is ever more prevalent. I would recommend this book as a must read, in particular for anyone eager to know about the mysterious world of genetics and it's most current direction. It's clear, concise, and thought-provoking, with just the right balance of science and humanity.
enjoyed it
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